Yarrow has been used in popular medicine for its anti-hemorrhagic, healing, and analgesic properties in various regions throughout the world. It was used by northern European and North American native people as a contraceptive, abortifacient, and emmenagogue. Some of these traditional and folk usages have been evaluated showing the potential medicinal use of the plant. The medicinal properties of Yarroware worldwide recognized and the plant is included in the national Pharmacopoeias of countries such as Germany, the Czech Republic, France, and Switzerland. As it is reviewed in this paper, the antioxidant and protective activity of various species of yarrow is reported frequently. This might be due to the high content of flavonoids and phenolics in these plants. It is noteworthy that oxidative stress is produced under diabetic conditions and yarrow plants are considered for high hypoglycemic activity. Among the medicinal properties of yarrow, their cytotoxic and antiulcer effects are important especially when the species contain immunomodulatory constituents. The activity of these plants against different bacteria, fungi, and parasites might be due to the presence of a broad range of secondary active metabolites such as flavonoids, phenolic acids, coumarins, terpenoids (monoterpenes, sesquiterpenes, diterpenes, triterpenes) and sterols which have been isolated. Finally, the presence of anti-inflammatory compounds such as sesquiterpenes and alkamides is another reason for the importance of these plants as the potential source of medicinal compounds and drugs in the future. (https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3232110/)